Based on the graphic novel WILSON written by Daniel Clowes, Woody Harrelson stars as Wilson, a lonely, neurotic and hilariously honest middle-aged misanthrope who reunites with his estranged wife (Laura Dern) and gets a shot at happiness when he learns he has a teenage daughter (Isabella Amara) he has never met.

In his uniquely outrageous and slightly twisted way, he sets out to connect with her.